Check out the KB articles Q245563. It also may have to do with Power Management in general. I usually turn this off.

>>*snip
>>>
>>>There is only one user usering the application and the speed problem happens.
>>>They are not using any antivirus software.
>>>The clients are P2's with 64MB.
>>>
>>
>>What else is currently running on the client machine? What OS is running?
>
>It's 98 for clients and the server is a brand new win 2000 server just for
>the application.
>We tried with every single program closed on the clients and it made
>no difference.
>
>I remember once something about the netcard set either set to
>Duplex or Duplex was turned off and performnace was increased drastically or something like that. But I'm far from a network wiz. Does this give you any ideas?